what is Rosacea

Rosacea is a common chronic inflammatory disorder of the hair follicles, sebaceous glands and vasculature of the face. The role of Demodex mite in the pathogenesis of Rosacea is controversial. Rosacea sufferers have recurrent flushing, exacerbated by heat (shower, hot drinks), spicy foods, sunlight, cold, alcohol, and stress. They have sensitive skin, and may complain of dry and gritty eyes. The peak incidence of Rosacea is 30—50 yr; Females being more affected than Males. Rosacea sufferers may develop erythema, telangiectases, papules, and pustules of central face; there are no comedones in contrast to acne. Sebaceous hyperplasia, seborrheic dermatitis and facial lymphedema are also more common. There are 4 Major Subtypes of Rosacea: Erythematotelangiectatic, papulopustular, ocular, and phymatous. Chronic inflammation may progress to rhinophyma (enlarged nose; in males). Ocular involvement is also common (e.g., gritty, conjunctival injection, styes, photophobia). Investigations include clinical diagnosis; uncommonly, skin biopsy is indicated to rule out lupus or sarcoidosis. Similar conditions that needs to be differentiated from Rosacea are: Acne, lupus erythematosus, perioral dermatitis, sarcoidosis, seborrheic dermatitis. Treatment of Rosacea is based on severity and subtype. Lifestyle modification: Avoid triggers; sun protection and avoidance; facial massage for lymphedema. Topical antibiotics: Metronidazole 0.75% gel or 1% cream bid. Sodium sulfacetamide lotion 10% bid. Oral antibiotics (moderate to severe cases with inflammatory papulopustular component): Tetracycline 500 mg po bid Minocycline 100 mg po od—bid. Doxycycline 20 mg po bid (subantimicrobial dose therapy) or 100 mg po qd–bid. Isotretinoin (low dose); less commonly, topical retinoids may be used. Laser therapy (e.g., PDL, IPL) for telangiectases and ablative laser (e.g., CO2) for rhinophyma. Camouflage makeup (e.g., Dermablend, Covermark) for erythema. Ophthalmologist to assess for ocular Rosacea (blepharitis, conjunctivitis, episcleritis).

Thursday, December 20, 2007

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